Target Information

General Information of This Target
Target ID
BTDT10034
Target Name
Coagulation factor VII
Target Bioclass
Coagulation factor
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Hemextin A Inhibition constant
25 nM
 [1], [2], [3]
 Toxin Info    Hemextin B Inhibition constant
50 nM
 [1], [3]
 Toxin Info    Hemextin A IC50
100 nM
 [1], [2], [3]
 Toxin Info    Hemextin B IC50
100 nM
 [1], [3]
 Toxin Info    Ringhalexin IC50
123.8 nM
 [4]
References
Ref 1 Hemextin AB complex, a unique anticoagulant protein complex from Hemachatus haemachatus (African Ringhals cobra) venom that inhibits clot initiation and factor VIIa activity. J Biol Chem. 2005 Dec 30;280(52):42601-11. doi: 10.1074/jbc.M508987200. Epub 2005 Oct 4.
Ref 2 Crystallization and preliminary X-ray diffraction analysis of hemextin A: a unique anticoagulant protein from Hemachatus haemachatus venom. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt 8):701-3. doi: 10.1107/S1744309107034239. Epub 2007 Jul 21.
Ref 3 Biophysical characterization of anticoagulant hemextin AB complex from the venom of snake Hemachatus haemachatus. Biophys J. 2007 Dec 1;93(11):3963-76. doi: 10.1529/biophysj.106.100164. Epub 2007 Aug 17.
Ref 4 Ringhalexin from Hemachatus haemachatus: A novel inhibitor of extrinsic tenase complex. Sci Rep. 2016 May 13;6:25935. doi: 10.1038/srep25935.
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