Peptide Information

General Information of This Peptide
Peptide ID
BTDP005346
Peptide Name
Hemextin B
Symonym
Hemachatus extrinsic tenase inhibitor B
Species
Hemachatus haemachatus (Rinkhals) (Sepedon haemachatus)
Uniprot Name
3SBB_HEMHA
Alphafold ID
P0DQH4
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DQH4
Sequence
LKCKNKVVPFLKCKNKVVPFLCYKMTLKKVTPKIKRG
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Sequence Length
37
Mass (Da)
4323
Sequence Removed Signal Peptide
LKCKNKVVPFLKCKNKVVPFLCYKMTLKKVTPKIKRG
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        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Hemachatus
Species: Hemachatus haemachatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    coagulation factor VIIa (F7) Inhibition constant
50 nM
 . . [1], [2]
 Target Info    coagulation factor VIIa (F7) IC50
100 nM
 . . [1], [2]
References
Ref 1 Hemextin AB complex, a unique anticoagulant protein complex from Hemachatus haemachatus (African Ringhals cobra) venom that inhibits clot initiation and factor VIIa activity. J Biol Chem. 2005 Dec 30;280(52):42601-11. doi: 10.1074/jbc.M508987200. Epub 2005 Oct 4.
Ref 2 Biophysical characterization of anticoagulant hemextin AB complex from the venom of snake Hemachatus haemachatus. Biophys J. 2007 Dec 1;93(11):3963-76. doi: 10.1529/biophysj.106.100164. Epub 2007 Aug 17.
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