Peptide Information

General Information of This Peptide
Peptide ID
BTDP005345
Peptide Name
Hemextin A
Symonym
Hemachatus extrinsic tenase inhibitor A
Species
Hemachatus haemachatus (Rinkhals) (Sepedon haemachatus)
Uniprot Name
3SBA_HEMHA
Alphafold ID
P0DQH3
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DQH3
Sequence
LKCKNKLVPFLSKTCPEGKNLCYKMTLKKVTPKIKRG
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Sequence Length
37
Mass (Da)
4237
Sequence Removed Signal Peptide
LKCKNKLVPFLSKTCPEGKNLCYKMTLKKVTPKIKRG
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        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Hemachatus
Species: Hemachatus haemachatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    coagulation factor VIIa (F7) Inhibition constant
25 nM
 . . [1], [2], [3]
 Target Info    coagulation factor VIIa (F7) IC50
100 nM
 . . [1], [2], [3]
References
Ref 1 Hemextin AB complex, a unique anticoagulant protein complex from Hemachatus haemachatus (African Ringhals cobra) venom that inhibits clot initiation and factor VIIa activity. J Biol Chem. 2005 Dec 30;280(52):42601-11. doi: 10.1074/jbc.M508987200. Epub 2005 Oct 4.
Ref 2 Crystallization and preliminary X-ray diffraction analysis of hemextin A: a unique anticoagulant protein from Hemachatus haemachatus venom. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt 8):701-3. doi: 10.1107/S1744309107034239. Epub 2007 Jul 21.
Ref 3 Biophysical characterization of anticoagulant hemextin AB complex from the venom of snake Hemachatus haemachatus. Biophys J. 2007 Dec 1;93(11):3963-76. doi: 10.1529/biophysj.106.100164. Epub 2007 Aug 17.
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