Target Information

General Information of This Target
Target ID
BTDT10027
Target Name
Calcium-activated potassium channel
Target Bioclass
Transporter and channel
Taxonomy ID
10116
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    IbTx (D19Y,Y36F) Dissociation constant
0.02 nM
 [1]
 Toxin Info    IbTx (D19C) Dissociation constant
0.022 nM
 [2]
 Toxin Info    ScyTx (F2Y) Dissociation constant
0.08 nM
 [3]
 Toxin Info    ChTX Dissociation constant
0.1 nM
 [4]
 Toxin Info    ChTX Dissociation constant
860 nM
 [5]
References
Ref 1 [125I]Iberiotoxin-D19Y/Y36F, the first selective, high specific activity radioligand for high-conductance calcium-activated potassium channels. Biochemistry. 1997 Feb 18;36(7):1943-52. doi: 10.1021/bi962074m.
Ref 2 Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: targeting to axons and nerve terminals. J Neurosci. 1996 Feb 1;16(3):955-63. doi: 10.1523/JNEUROSCI.16-03-00955.1996.
Ref 3 Leiurotoxin I (scyllatoxin), a peptide ligand for Ca2(+)-activated K+ channels. Chemical synthesis, radiolabeling, and receptor characterization. J Biol Chem. 1990 Mar 15;265(8):4753-9.
Ref 4 Characterization of high affinity binding sites for charybdotoxin in sarcolemmal membranes from bovine aortic smooth muscle. Evidence for a direct association with the high conductance calcium-activated potassium channel. J Biol Chem. 1989 Dec 15;264(35):20902-9.
Ref 5 Analysis of the blocking activity of charybdotoxin homologs and iodinated derivatives against Ca2+-activated K+ channels. J Membr Biol. 1989 Aug;109(3):269-81. doi: 10.1007/BF01870284.
Ref 6 Photoaffinity labeling of components of the apamin-sensitive K+ channel in neuronal membranes. J Biol Chem. 1985 Apr 10;260(7):3895-8.
Ref 7 Photolabile derivatives of 125I-apamin: defining the structural criteria required for labeling high and low molecular mass polypeptides associated with small conductance Ca(2+)-activated K+ channels. Biochemistry. 1996 Jun 18;35(24):7917-27. doi: 10.1021/bi9602371.
Ref 8 Preparation of a pure monoiodo derivative of the bee venom neurotoxin apamin and its binding properties to rat brain synaptosomes. J Biol Chem. 1982 Mar 25;257(6):2762-9.
Ref 9 Molecular structure of rat brain apamin receptor: differential photoaffinity labeling of putative K+ channel subunits and target size analysis. Biochemistry. 1986 Jul 15;25(14):4051-7. doi: 10.1021/bi00362a010.
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