Target Information

General Information of This Target
Target ID
BTDT10015
Target Name
Alpha-1A adrenergic receptor
Target Bioclass
Transporter and channel
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Adrenergic toxin rho-elapitoxin-Dp1b Inhibition constant
0.37 nM
 [1], [2]
 Toxin Info    Toxin AdTx1 Affinity
0.35 nM
 [3- 9]
References
Ref 1 The amino acid sequence of protein CM-3 from Dendroaspis polylepis polylepis (black mamba) venom. Int J Biochem. 1985;17(6):695-9. doi: 10.1016/0020-711x(85)90367-2.
Ref 2 New -adrenergic property for synthetic MT and CM-3 three-finger fold toxins from black mamba. Toxicon. 2013 Dec 1;75:160-7. doi: 10.1016/j.toxicon.2013.04.017. Epub 2013 May 3.
Ref 3 Isolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the alpha1A-adrenoceptor. Br J Pharmacol. 2010 Jan 1;159(2):316-25. doi: 10.1111/j.1476-5381.2009.00532.x. Epub 2009 Dec 15.
Ref 4 G protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors. Toxicon. 2012 Mar 15;59(4):487-96. doi: 10.1016/j.toxicon.2011.03.009. Epub 2011 Mar 22.
Ref 5 Effects of -Da1a a peptidic (1) (A) -adrenoceptor antagonist in human isolated prostatic adenoma and anaesthetized rats. Br J Pharmacol. 2013 Feb;168(3):618-31. doi: 10.1111/j.1476-5381.2012.02231.x.
Ref 6 Orthosteric binding of -Da1a, a natural peptide of snake venom interacting selectively with the 1A-adrenoceptor. PLoS One. 2013 Jul 25;8(7):e68841. doi: 10.1371/journal.pone.0068841. Print 2013.
Ref 7 Polypharmacology profiles and phylogenetic analysis of three-finger toxins from mamba venom: case of aminergic toxins. Biochimie. 2014 Aug;103:109-17. doi: 10.1016/j.biochi.2014.04.009. Epub 2014 May 1.
Ref 8 Crystallization of recombinant green mamba -Da1a toxin during a lyophilization procedure and its structure determination. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):704-9. doi: 10.1107/S1744309113011470. Epub 2013 May 29.
Ref 9 Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins. Sci Rep. 2017 Jun 2;7(1):2701. doi: 10.1038/s41598-017-02953-0.
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