Peptide Information

General Information of This Peptide
Peptide ID
BTDP006711
Peptide Name
Toxin AdTx1
Symonym
Rho-elapitoxin-Da1a
Species
Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Uniprot Name
3SI1A_DENAN
Alphafold ID
P85092
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 4IYE
Sequence
LTCVTSKSIFGITTEDCPDGQNLCFKRRHYVVPKIYDSTRGCAATCPIPENYDSIHCCKT
DKCNE
   Click to Show/Hide
Sequence Length
65
Mass (Da)
7291
Sequence Removed Signal Peptide
LTCVTSKSIFGITTEDCPDGQNLCFKRRHYVVPKIYDSTRGCAATCPIPENYDSIHCCKT
DKCNE
   Click to Show/Hide
Disulfide Bond
3-24;17-42;46-57;58-63
PDB ID
4IYE , 5MG9
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Dendroaspis
Species: Dendroaspis angusticeps
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    alpha-1A adrenergic receptor (ADRA1A) Affinity
0.35 nM
 . . [1- 7]
References
Ref 1 Isolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the alpha1A-adrenoceptor. Br J Pharmacol. 2010 Jan 1;159(2):316-25. doi: 10.1111/j.1476-5381.2009.00532.x. Epub 2009 Dec 15.
Ref 2 G protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors. Toxicon. 2012 Mar 15;59(4):487-96. doi: 10.1016/j.toxicon.2011.03.009. Epub 2011 Mar 22.
Ref 3 Effects of -Da1a a peptidic (1) (A) -adrenoceptor antagonist in human isolated prostatic adenoma and anaesthetized rats. Br J Pharmacol. 2013 Feb;168(3):618-31. doi: 10.1111/j.1476-5381.2012.02231.x.
Ref 4 Orthosteric binding of -Da1a, a natural peptide of snake venom interacting selectively with the 1A-adrenoceptor. PLoS One. 2013 Jul 25;8(7):e68841. doi: 10.1371/journal.pone.0068841. Print 2013.
Ref 5 Polypharmacology profiles and phylogenetic analysis of three-finger toxins from mamba venom: case of aminergic toxins. Biochimie. 2014 Aug;103:109-17. doi: 10.1016/j.biochi.2014.04.009. Epub 2014 May 1.
Ref 6 Crystallization of recombinant green mamba -Da1a toxin during a lyophilization procedure and its structure determination. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):704-9. doi: 10.1107/S1744309113011470. Epub 2013 May 29.
Ref 7 Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins. Sci Rep. 2017 Jun 2;7(1):2701. doi: 10.1038/s41598-017-02953-0.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.