Target Information

General Information of This Target
Target ID
BTDT00178
Target Name
Acetylcholine receptor subunit alpha (chrna1)
Target Bioclass
Receptor
Uniprot ID
Q98880
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Gene Name
chrna1
Gene ID
30725
Synonym
nic1
Sequence
MNYFILILPILPYLYGPAVCSEDETRLVKTLFTGYNKVVRPVSHFKDPVVVTVGLQLIQL
ISVDEVNQIVTSNVRLKQQWKDVHLQWNPDDYGGIRKIRIPSTDLWKPDLVLYNNADGDF
AIVHETKVLLEHTGMITWTPPAIFKSYCEIVVLHFPFDLQNCSMKLGTWTYDGNLVIINP
DSDRPDLSNFMESGEWVMKDYRSWKHWVYYACCPDTPYLDITYHFLLLRLPLYFIVNVII
PCMLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLF
TMIFVIASIIITVIVINTHHRSPSTHIMPAWVRKIFIDTIPNMMFFSTMKRPSQERQEKR
LFPADFDISDISGKPMPASVTYHSPITKNPDVRSAIEGVKYIADTMKSDEESNNAAEEWK
FVAMVLDHILLCVFMAVCIIGTLGVFAGRLIELSML

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Family
the ligand-gated ion channel (TC 1.A.9) family
Function
Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

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Taxonomy ID
7955
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Kingdom: Metazoa
Phylum: Chordata
Class: Actinopteri
Order: Cypriniformes
Family: Danionidae
Genus: Danio
Species: Danio rerio
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Alpha-conotoxin EI IC50
58 - 100 nM
 [1- 6]
 Toxin Info    Conotoxin MIIIJ IC50
0.1 μM
 [5]
References
Ref 1 alpha-Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity. Biochemistry. 1995 Nov 7;34(44):14519-26. doi: 10.1021/bi00044a030.
Ref 2 Discovery and characterization of EII(B,) a new -conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry. Toxicon. 2017 May;130:1-10. doi: 10.1016/j.toxicon.2017.02.023. Epub 2017 Feb 24.
Ref 3 Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS J. 2007 Aug;274(15):3972-85. doi: 10.1111/j.1742-4658.2007.05931.x. Epub 2007 Jul 16.
Ref 4 Inhibition of cholinergic pathways in Drosophila melanogaster by -conotoxins. FASEB J. 2015 Mar;29(3):1011-8. doi: 10.1096/fj.14-262733. Epub 2014 Dec 2.
Ref 5 M-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish. Toxins (Basel). 2020 Mar 21;12(3):197. doi: 10.3390/toxins12030197.
Ref 6 Solution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the alpha 1/delta subunit interface of torpedo nicotinic acetylcholine receptor. J Biol Chem. 2001 Dec 28;276(52):49028-33. doi: 10.1074/jbc.M107798200. Epub 2001 Oct 18.
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