Peptide Information

General Information of This Peptide
Peptide ID
BTDP006016
Peptide Name
Alpha-conotoxin EI
Species
Conus ermineus (Agate cone) (Chelyconus ermineus)
Uniprot Name
CA1A_CONER
Alphafold ID
P50982
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1K64
Sequence
MFTVFLLVVLATTVGSFTLDRASDGRDAAANDKASDLIALTARRDPCCYHPTCNMSNPQI
CG
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Sequence Length
62
Mass (Da)
6637
Signal Sequence
MFTVFLLVVLATTVGS
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Sequence Removed Signal Peptide
FTLDRASDGRDAAANDKASDLIALTARRDPCCYHPTCNMSNPQICG
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Disulfide Bond
47-53;48-61
PDB ID
1K64
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus ermineus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    postsynaptic nAChR IC50
58 - 100 nM
 . . [1- 6]
References
Ref 1 alpha-Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity. Biochemistry. 1995 Nov 7;34(44):14519-26. doi: 10.1021/bi00044a030.
Ref 2 Discovery and characterization of EII(B,) a new -conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry. Toxicon. 2017 May;130:1-10. doi: 10.1016/j.toxicon.2017.02.023. Epub 2017 Feb 24.
Ref 3 Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS J. 2007 Aug;274(15):3972-85. doi: 10.1111/j.1742-4658.2007.05931.x. Epub 2007 Jul 16.
Ref 4 Inhibition of cholinergic pathways in Drosophila melanogaster by -conotoxins. FASEB J. 2015 Mar;29(3):1011-8. doi: 10.1096/fj.14-262733. Epub 2014 Dec 2.
Ref 5 M-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish. Toxins (Basel). 2020 Mar 21;12(3):197. doi: 10.3390/toxins12030197.
Ref 6 Solution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the alpha 1/delta subunit interface of torpedo nicotinic acetylcholine receptor. J Biol Chem. 2001 Dec 28;276(52):49028-33. doi: 10.1074/jbc.M107798200. Epub 2001 Oct 18.
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