Peptide Information

General Information of This Peptide
Peptide ID
BTDP005362
Peptide Name
Conotoxin MIIIJ
Symonym
AlphaM-MIIIJ
Species
Conus magus (Magical cone)
Uniprot Name
CM3J_CONMA
Alphafold ID
P0DQM8
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DQM8
Sequence
QKCCSGGSCPLYFRDRLICPCC
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Sequence Length
22
Mass (Da)
2453
Sequence Removed Signal Peptide
QKCCSGGSCPLYFRDRLICPCC
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Disulfide Bond
3-21;4-19;9-22
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus magus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR IC50
0.1 μM
 . . [1]
 Target Info    postsynaptic nAChR IC50
0.1 μM
 . . [1]
 Target Info    nAChR IC50
0.1 μM
 . . [1]
 Target Info    nAChR alpha-1-beta-1-delta-epsilon IC50
3 - 45 μM
 . . [1]
 Target Info    nAChR alpha-1-beta-1-gamma-delta IC50
3 - 45 μM
 . . [1]
References
Ref 1 M-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish. Toxins (Basel). 2020 Mar 21;12(3):197. doi: 10.3390/toxins12030197.
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