Target Information

General Information of This Target
Target ID
BTDT00102
Target Name
Caveolin-3 (CAV3)
Target Bioclass
Transporter and channel
Uniprot ID
P56539
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Gene Name
CAV3
Gene ID
859
Synonym
M-caveolin
Sequence
MMAEEHTDLEAQIVKDIHCKEIDLVNRDPKNINEDIVKVDFEDVIAEPVGTYSFDGVWKV
SYTTFTVSKYWCYRLLSTLLGVPLALLWGFLFACISFCHIWAVVPCIKSYLIEIQCISHI
YSLCIRTFCNPLFAALGQVCSSIKVVLRKEV

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Family
the caveolin family
Function
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae.

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Taxonomy ID
9606
TCDB ID
1.F.1.2.1
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Mu/omega-theraphotoxin-Pmu1a Inhibition rate
90.8 %
 [1]
 Toxin Info    Omega-theraphotoxin-Avsp1a IC50
4.32 μM
 [2]
References
Ref 1 Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNa(V) 1.7 and hCa(V) 3 voltage-gated channels. FEBS J. 2023 Jul;290(14):3688-3702. doi: 10.1111/febs.16773. Epub 2023 Mar 23.
Ref 2 The Tarantula Toxin -Avsp1a Specifically Inhibits Human Ca(V)3.1 and Ca(V)3.3 via the Extracellular S3-S4 Loop of the Domain 1 Voltage-Sensor. Biomedicines. 2022 May 4;10(5):1066. doi: 10.3390/biomedicines10051066.
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