Peptide Information

General Information of This Peptide
Peptide ID
BTDP005452
Peptide Name
Mu/omega-theraphotoxin-Pmu1a
Symonym
Mu/omega-TRTX-Pmu1a
Species
Pterinochilus murinus (Mombasa golden starburst baboon spider)
Uniprot Name
TXM1A_PTEMU
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 8FEY
Sequence
ECRWFWGGCNNDADCCKHLECKRKWPHICLWDGTFT
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Sequence Length
36
Mass (Da)
4360
Sequence Removed Signal Peptide
ECRWFWGGCNNDADCCKHLECKRKWPHICLWDGTFT
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Disulfide Bond
2-16;9-21;15-29
PDB ID
8FEY
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Pterinochilus
Species: Pterinochilus murinus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Cav3.2 Inhibition rate
63.5 %
10 μM
 . [1]
 Target Info    Cav3.3 Inhibition rate
90.8 %
10 μM
 . [1]
 Target Info    Cav3.1 Inhibition rate
95.1 %
10 μM
 . [1]
 Target Info    Nav1.7 IC50
5.5 - 7 nM
 . . [1]
 Target Info    Nav1.6 IC50
9.9 nM
 . . [1]
 Target Info    Nav1.4 IC50
62.9 nM
 . . [1]
 Target Info    Cav3.2 IC50
955.4 nM
 . . [1]
References
Ref 1 Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNa(V) 1.7 and hCa(V) 3 voltage-gated channels. FEBS J. 2023 Jul;290(14):3688-3702. doi: 10.1111/febs.16773. Epub 2023 Mar 23.
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