Peptide Information

General Information of This Peptide
Peptide ID
BTDP008939
Peptide Name
Uro (K25A,T19Q,A25K)
Symonym
Uro (K25A,T19Q,A25K)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
GDIKCSGTRQCWGPCKKQTTCTNSKCMNGKCKCYGCV
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Mutant Sequence
GDIKCSGTRQCWGPCKKQQTCTNSKCMNGKCKCYGCV
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Sequence Length
37
Mass(Da)
4040
Sequence Removed Signal Peptide
GDIKCSGTRQCWGPCKKQQTCTNSKCMNGKCKCYGCV
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 IC50
67 nM
 .
Blocker
 [1]
 Target Info    Kv1.1 IC50
7.7 μM
 .
Blocker
 [1]
References
Ref 1 Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom. Biochem Pharmacol. 2020 Apr;174:113782. doi: 10.1016/j.bcp.2019.113782. Epub 2019 Dec 25.
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