Peptide Information

General Information of This Peptide

Peptide ID	BTDP008744
Peptide Name	HgTX1 (A19C)
Symonym	HgTX1 (A19C)
3D Structure	Download 2D Sequence Download FASTA 3D Structure Download PDB Source Predict by Alphafold2 ? Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence	TVIDVKCTSPKQCLPPCKAQFGIRAGAKCMNGKCKCYPH Click to Show/Hide
Mutant Sequence	TVIDVKCTSPKQCLPPCKCQFGIRAGAKCMNGKCKCYPH Click to Show/Hide
Sequence Length	39
Mass(Da)	4252
Sequence Removed Signal Peptide	TVIDVKCTSPKQCLPPCKCQFGIRAGAKCMNGKCKCYPH Click to Show/Hide
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N.A.

Full List of Activity Data of This Peptide Toxin

Target Name	Activity Data Type	Activity Data	Concentration	Note	Reference
Target Info Kv1.3	Dissociation constant	0.28 nM	.	Blocker	[1]
Target Info Kv1	IC50	2 pM	.	Blocker	[2]
Target Info Kv1	IC50	2 pM	.	Blocker	[2]
Target Info Kv1	IC50	3 pM	.	Blocker	[2]
Target Info Kv1	IC50	4 pM	.	Blocker	[2]
Target Info Kv1	IC50	5 pM	.	Blocker	[2]
Target Info Kv1	IC50	6.4 pM	.	Blocker	[2]
Target Info Kv1	IC50	7 pM	.	Blocker	[2]
Target Info Kv1	IC50	0.011 nM	.	Blocker	[2]

References

Ref 1	Ultrasensitive pharmacological characterisation of the voltage-gated potassium channel K(V)1.3 studied by single-molecule fluorescence microscopy. Histochem Cell Biol. 2002 Mar;117(3):197-202. doi: 10.1007/s00418-001-0374-y. Epub 2002 Jan 30.
Ref 2	Synthesis, characterization, and application of cy-dye- and alexa-dye-labeled hongotoxin(1) analogues. The first high affinity fluorescence probes for voltage-gated K+ channels. Bioconjug Chem. 2002 May-Jun;13(3):416-25. doi: 10.1021/bc015543s.

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