Peptide Information

General Information of This Peptide
Peptide ID
BTDP008736
Peptide Name
GPTX1 (N-Term. Ala)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF
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Mutant Sequence
ADCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF
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Sequence Length
35
Mass(Da)
4152
Sequence Removed Signal Peptide
ADCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF
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Disulfide Bond
3-18;10-24;17-31
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
370 nM
 . . [1]
 Target Info    Nav1.4 IC50
>4.8 μM
 . . [2]
 Target Info    Nav1.5 IC50
>5 μM
 . . [3]
 Target Info    Nav1.5 IC50
>5 μM
 . . [4]
References
Ref 1 Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel. J Med Chem. 2015 Mar 12;58(5):2299-314. doi: 10.1021/jm501765v. Epub 2015 Feb 19.
Ref 2 Rapidly growing mycobacteria in Singapore, 2006-2011. Clin Microbiol Infect. 2015 Mar;21(3):236-41. doi: 10.1016/j.cmi.2014.10.018. Epub 2014 Nov 4.
Ref 3 Subcutaneously administered antibiotics: a national survey of current practice from the French Infectious Diseases (SPILF) and Geriatric Medicine (SFGG) society networks. Clin Microbiol Infect. 2015 Apr;21(4):370.e1-3. doi: 10.1016/j.cmi.2014.11.017. Epub 2014 Nov 23.
Ref 4 Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1. J Med Chem. 2016 Mar 24;59(6):2704-17. doi: 10.1021/acs.jmedchem.5b01947. Epub 2016 Mar 10.
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