Peptide Information

General Information of This Peptide

Peptide ID	BTDP008668
Peptide Name	Potassium channel toxin alpha-KTx 6.4
Symonym	Potassium channel-blocking toxin 4
Species	Pandinus imperator (Emperor scorpion)
Uniprot Name	KAX64_PANIM
Alphafold ID	P58498
3D Structure	Download 2D Sequence Download FASTA 3D Structure Download PDB Source RSCB PDB: 1N8M
Sequence	IEAIRCGGSRDCYRPCQKRTGCPNAKCINKTCKCYGCS Click to Show/Hide
Sequence Length	38
Mass (Da)	4188
Sequence Removed Signal Peptide	IEAIRCGGSRDCYRPCQKRTGCPNAKCINKTCKCYGCS Click to Show/Hide
Disulfide Bond	6-27;12-32;16-34;22-37
PDB ID	1N8M
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Arthropoda Class: Arachnida Order: Scorpiones Family: Scorpionidae Genus: Pandinus Species: Pandinus imperator

Full List of Activity Data of This Peptide Toxin

Target Name	Activity Data Type	Activity Data	Concentration	Note	Reference
Target Info Kv1.3	Inhibition rate	.	100 μM	Blocker	[2]
Target Info Kv1	Inhibition rate	.	100 μM	Blocker	[2]
Target Info Kv1.2	IC50	8 pM	.	Blocker	[1], [2], [3]
Target Info Shaker	IC50	3 nM	.	Blocker	[2]
Target Info KCa2	IC50	500 nM	.	Blocker	[1], [2], [3]

References

Ref 1	Two similar peptides from the venom of the scorpion Pandinus imperator, one highly effective blocker and the other inactive on K+ channels. Toxicon. 1998 May;36(5):759-70. doi: 10.1016/s0041-0101(97)00163-3.
Ref 2	Synthesis and characterization of Pi4, a scorpion toxin from Pandinus imperator that acts on K+ channels. Eur J Biochem. 2003 Sep;270(17):3583-92. doi: 10.1046/j.1432-1033.2003.03743.x.
Ref 3	Solution structure of Pi4, a short four-disulfide-bridged scorpion toxin specific of potassium channels. Protein Sci. 2003 Sep;12(9):1844-54. doi: 10.1110/ps.03186703.

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