Peptide Information

General Information of This Peptide
Peptide ID
BTDP008665
Peptide Name
Kappa-sparatoxin-Hv1b
Symonym
Heteropodatoxin-2; Toxin KJ6
Species
Heteropoda venatoria (Brown huntsman spider) (Aranea venatoria)
Uniprot Name
TXHP2_HETVE
Alphafold ID
P58426
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1EMX
Sequence
DDCGKLFSGCDTNADCCEGYVCRLWCKLDW
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Sequence Length
30
Mass (Da)
3420
Sequence Removed Signal Peptide
DDCGKLFSGCDTNADCCEGYVCRLWCKLDW
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Disulfide Bond
3-17;10-22;16-26
PDB ID
1EMX
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Sparassidae
Genus: Heteropoda
Species: Heteropoda venatoria
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv4.3 Dissociation constant
2.3 μM
 .
Modifier
 [2]
 Target Info    Kv4.1 Dissociation constant
7.1 μM
 .
Modifier
 [2]
 Target Info    Kv1.4 Inhibition rate .
2 μM
Modifier
 [2]
 Target Info    Kv4.2 IC50
100 nM
 .
Modifier
 [2]
References
Ref 1 Heteropodatoxins: peptides isolated from spider venom that block Kv4.2 potassium channels. Mol Pharmacol. 1997 Mar;51(3):491-8.
Ref 2 Heteropoda toxin 2 is a gating modifier toxin specific for voltage-gated K+ channels of the Kv4 family. Toxicon. 2005 Mar 15;45(4):431-42. doi: 10.1016/j.toxicon.2004.11.015.
Ref 3 Solution structure of hpTX2, a toxin from Heteropoda venatoria spider that blocks Kv4.2 potassium channel. Protein Sci. 2000 Nov;9(11):2059-67.
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