Peptide Information

General Information of This Peptide
Peptide ID
BTDP008627
Peptide Name
Potassium channel toxin alpha-KTx 3.10
Symonym
BoiTx1
Species
Buthus occitanus israelis (Common yellow scorpion) (Buthus israelis)
Uniprot Name
KAX3A_BUTOS
Alphafold ID
P0C908
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 6ATM
Sequence
MKVFFAVLIALFVCSMVIGIHGGVPINVKCRGSRDCLDPCKKAGMRFGKCINSKCHCTP
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Sequence Length
59
Mass (Da)
6402
Signal Sequence
MKVFFAVLIALFVCSMVIGIHG
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Sequence Removed Signal Peptide
GVPINVKCRGSRDCLDPCKKAGMRFGKCINSKCHCTP
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Disulfide Bond
30-50;36-55;40-57
PDB ID
6ATM
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Buthus
Species: Buthus occitanus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Shaker IC50
3.5 nM
 .
Blocker
 [1]
 Target Info    Kv1 IC50
550 nM
 .
Blocker
 [1], [2]
 Target Info    Kv1.3 IC50
550 nM
 .
Blocker
 [1]
References
Ref 1 Isolation of the first toxin from the scorpion Buthus occitanus israelis showing preference for Shaker potassium channels. FEBS Lett. 2007 May 29;581(13):2478-84. doi: 10.1016/j.febslet.2007.04.065. Epub 2007 Apr 30.
Ref 2 Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub 2018 Feb 26.
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