Peptide Information

General Information of This Peptide
Peptide ID
BTDP008625
Peptide Name
Potassium channel toxin alpha-KTx 3.12
Symonym
Kaliotoxin analog
Species
Androctonus amoreuxi (African fattail scorpion) (Scorpio amoreuxi)
Uniprot Name
KAX3C_ANDAM
Alphafold ID
P0C8R1
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P0C8R1
Sequence
GVEINVKCTGSHQCIKPCKDAGMRFGKCINRKCHCTPK
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Sequence Length
38
Mass (Da)
4192
Sequence Removed Signal Peptide
GVEINVKCTGSHQCIKPCKDAGMRFGKCINRKCHCTPK
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Disulfide Bond
8-28;14-33;18-35
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Androctonus
Species: Androctonus amoreuxi
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1 Inhibition rate .
750 nM
Blocker
 [1]
 Target Info    Kv1.3 IC50
1.1 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
10.4 nM
 .
Blocker
 [1]
References
Ref 1 A new Kaliotoxin selective towards Kv1.3 and Kv1.2 but not Kv1.1 channels expressed in oocytes. Biochem Biophys Res Commun. 2008 Nov 21;376(3):525-30. doi: 10.1016/j.bbrc.2008.09.033. Epub 2008 Sep 18.
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