Peptide Information

General Information of This Peptide
Peptide ID
BTDP008607
Peptide Name
Defensin beta 4A
Symonym
Beta-defensin 2; Defensin, beta 2; Skin-antimicrobial peptide 1
Species
Homo sapiens (Human)
Uniprot Name
DFB4A_HUMAN
Alphafold ID
O15263
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1E4Q
Sequence
MRVLYLLFSFLFIFLMPLPGVFGGIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKC
CKKP
   Click to Show/Hide
Sequence Length
64
Mass (Da)
7038
Sequence Removed Signal Peptide
GIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP
   Click to Show/Hide
Disulfide Bond
31-60;38-53;43-61
PDB ID
1E4Q , 1FD3 , 1FD4 , 1FQQ , 6CS9
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv7.1 Inhibition rate
12 %
1 μM
 . [1]
 Target Info    Kv1.2 Inhibition rate
16 %
1 μM
 . [1]
 Target Info    KCa1.1 Effective concentration 50
1.4 nM
 . . [2]
 Target Info    Kv1.3 IC50
0.022 nM
 . . [1]
References
Ref 1 Endogenous animal toxin-like human -defensin 2 inhibits own K(+) channels through interaction with channel extracellular pore region. Cell Mol Life Sci. 2015 Feb;72(4):845-53. doi: 10.1007/s00018-014-1715-z. Epub 2014 Sep 20.
Ref 2 Human -defensin 2 is a novel opener of Ca2+-activated potassium channels and induces vasodilation and hypotension in monkeys. Hypertension. 2013 Aug;62(2):415-25. doi: 10.1161/HYPERTENSIONAHA.111.01076. Epub 2013 Jun 3.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.