Peptide Information

General Information of This Peptide
Peptide ID
BTDP008573
Peptide Name
U-Asilidin(12)-Dg3b
Species
Dolopus genitalis (Giant Australian assassin fly) (Asilus genitalis)
Uniprot Name
ASC3B_DOLGE
Alphafold ID
A0A3G5BIB1
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 6PX8
Sequence
MRFLNIFLFFAVMIAFVSASPVLEEEEIDIEPRITCDLIGNERLCVVHCLAKGFRGGWCD
SRKVCNCRR
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Sequence Length
69
Mass (Da)
7939
Signal Sequence
MRFLNIFLFFAVMIAFVSA
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Sequence Removed Signal Peptide
SPVLEEEEIDIEPRITCDLIGNERLCVVHCLAKGFRGGWCDSRKVCNCRR
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Disulfide Bond
36-59;45-65;49-67
PDB ID
6PX8
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Arthropoda
Class: Insecta
Order: Diptera
Family: Asilidae
Genus: Dolopus
Species: Dolopus genitalis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Inhibition rate .
1 μM
Activator
 [1], [2]
 Target Info    Shaker-IR Inhibition rate .
1 μM
Activator
 [1], [2]
 Target Info    Kv2.1 Inhibition rate .
1 μM
Activator
 [1], [2]
 Target Info    KCa1.1 Inhibition rate .
1 μM
Activator
 [1], [2]
 Target Info    Kv10 Inhibition rate .
1 μM
Activator
 [1], [2]
 Target Info    Kv11 IC50
1 μM
 .
Activator
 [1], [2]
References
Ref 1 Buzz Kill: Function and Proteomic Composition of Venom from the Giant Assassin Fly Dolopus genitalis (Diptera: Asilidae). Toxins (Basel). 2018 Nov 5;10(11):456. doi: 10.3390/toxins10110456.
Ref 2 Weaponisation 'on the fly': Convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies. Insect Biochem Mol Biol. 2020 Mar;118:103310. doi: 10.1016/j.ibmb.2019.103310. Epub 2019 Dec 21.
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