Peptide Information

General Information of This Peptide
Peptide ID
BTDP008555
Peptide Name
Thrombin-like enzyme collinein-1
Symonym
Fibrinogen-clotting enzyme; Snake venom serine protease
Species
Crotalus durissus collilineatus (Brazilian rattlesnake)
Uniprot Name
VSP1_CRODO
Alphafold ID
A0A0S4FKT4
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: A0A0S4FKT4
Sequence
VIGGDECNINEHNFLVALYEYWSQSFLCGGTLINGEWVLTAAHCDRKHILIYVGVHDRSV
QFDKEQRRFPKEKYFFNCRNNFTKWDKDIMLIRLNKPVSYSEHIAPLSLPSSPPIVGSVC
RVMGWGTIKSPQETLPDVPHCANINLLDYEVCRTAHPQFRLPATIRILCAGVLEGGIDTC
HRDSGGPLICNGEFQGIVSWGDGSCAQPDKPALYSKVFDHLDWIQNIIAGSETVNCPS
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Sequence Length
238
Mass (Da)
26664
Sequence Removed Signal Peptide
VIGGDECNINEHNFLVALYEYWSQSFLCGGTLINGEWVLTAAHCDRKHILIYVGVHDRSV
QFDKEQRRFPKEKYFFNCRNNFTKWDKDIMLIRLNKPVSYSEHIAPLSLPSSPPIVGSVC
RVMGWGTIKSPQETLPDVPHCANINLLDYEVCRTAHPQFRLPATIRILCAGVLEGGIDTC
HRDSGGPLICNGEFQGIVSWGDGSCAQPDKPALYSKVFDHLDWIQNIIAGSETVNCPS
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Disulfide Bond
7-141;28-44;78-236;120-190;152-169;180-205
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Viperidae
Genus: Crotalus
Species: Crotalus durissus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Shaker-IR Inhibition rate .
5 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.4 Inhibition rate .
5 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Kv2.1 Inhibition rate .
5 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Kv11 Inhibition rate
5 %
5 μM
Blocker
 [1], [2], [3], [4]
 Target Info    Kv10 IC50
2.5 μM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv10.1 IC50
2.5 μM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv10.1 IC50
2.5 μM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv10.1 IC50
2.5 μM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv10.1 IC50
4.2 μM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv10.1 IC50
4.2 μM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv10.1 IC50
4.2 μM
 .
Blocker
 [1], [2], [3], [4]
References
Ref 1 Expression of a new serine protease from Crotalus durissus collilineatus venom in Pichia pastoris and functional comparison with the native enzyme. Appl Microbiol Biotechnol. 2015 Dec;99(23):9971-86. doi: 10.1007/s00253-015-6836-2. Epub 2015 Jul 31.
Ref 2 Functional and biological insights of rCollinein-1, a recombinant serine protease from Crotalus durissus collilineatus. J Venom Anim Toxins Incl Trop Dis. 2019 Apr 8;25:e147118. doi: 10.1590/1678-9199-JVATITD-1471-18. eCollection 2019.
Ref 3 Beyond hemostasis: a snake venom serine protease with potassium channel blocking and potential antitumor activities. Sci Rep. 2020 Mar 11;10(1):4476. doi: 10.1038/s41598-020-61258-x.
Ref 4 Towards toxin PEGylation: The example of rCollinein-1, a snake venom thrombin-like enzyme, as a PEGylated biopharmaceutical prototype. Int J Biol Macromol. 2021 Nov 1;190:564-573. doi: 10.1016/j.ijbiomac.2021.09.004. Epub 2021 Sep 7.
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