Peptide Information

General Information of This Peptide
Peptide ID
BTDP008544
Peptide Name
Potassium channel toxin MeuTXKalpha3
Symonym
Potassium channel toxin alpha-KTx
Species
Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
Uniprot Name
KAXU3_MESEU
Alphafold ID
E4VP04
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: E4VP04
Sequence
MKNYCGIITLFLAIISATGVFCVDFPNKGGKCDRKECRKTCKKLNYRGKCFPNYCRCFPG
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Sequence Length
60
Mass (Da)
6822
Signal Sequence
MKNYCGIITLFLAIISATGVFC
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Sequence Removed Signal Peptide
VDFPNKGGKCDRKECRKTCKKLNYRGKCFPNYCRCFPG
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Disulfide Bond
32-50;37-55;41-57
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus eupeus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Inhibition rate
6 %
100 μM
Blocker
 [2]
 Target Info    Kv1.3 Inhibition rate
12 %
100 μM
Blocker
 [2]
 Target Info    Shaker-IR Inhibition rate
28 %
100 μM
Blocker
 [2]
 Target Info    Kv1 Inhibition rate
35 %
100 μM
Blocker
 [2]
References
Ref 1 Molecular diversity and functional evolution of scorpion potassium channel toxins. Mol Cell Proteomics. 2011 Feb;10(2):M110.002832. doi: 10.1074/mcp.M110.002832. Epub 2010 Sep 30.
Ref 2 A single-point mutation enhances dual functionality of a scorpion toxin. Comp Biochem Physiol C Toxicol Pharmacol. 2016 Jan;179:72-8. doi: 10.1016/j.cbpc.2015.09.002. Epub 2015 Sep 7.
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