Peptide Information

General Information of This Peptide
Peptide ID
BTDP008528
Peptide Name
Potassium channel toxin alpha-KTx 9.5
Symonym
Kbot1
Species
Buthus occitanus tunetanus (Common European scorpion) (Buthus tunetanus)
Uniprot Name
KAX95_BUTOC
Alphafold ID
P84744
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P84744
Sequence
VGCEECPMHCKGKHAVPTCDDGVCNCNV
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Sequence Length
28
Mass (Da)
2949
Sequence Removed Signal Peptide
VGCEECPMHCKGKHAVPTCDDGVCNCNV
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Disulfide Bond
3-19;6-24;10-26
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Buthus
Species: Buthus occitanus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 IC50
2.5 nM
 .
Blocker
 [1]
 Target Info    Kv1.2 IC50
2.5 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
15 nM
 .
Blocker
 [1]
 Target Info    Kv1.3 IC50
15 nM
 .
Blocker
 [1]
 Target Info    Kv1.1 IC50
145 nM
 .
Blocker
 [1]
 Target Info    Kv1 IC50
145 nM
 .
Blocker
 [1]
References
Ref 1 Kbot1, a three disulfide bridges toxin from Buthus occitanus tunetanus venom highly active on both SK and Kv channels. Peptides. 2004 Apr;25(4):637-45. doi: 10.1016/j.peptides.2004.02.017.
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