Peptide Information

General Information of This Peptide
Peptide ID
BTDP008525
Peptide Name
Potassium channel toxin alpha-KTx 9.2
Symonym
Neurotoxin BmP03
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
KAX92_MESMA
Alphafold ID
Q9U8D1
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1WM8
Sequence
MSRLFTLVLIVLAMNVMMAIISDPVVEAVGCEECPMHCKGKNANPTCDDGVCNCNV
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Sequence Length
56
Mass (Da)
6001
Sequence Removed Signal Peptide
MSRLFTLVLIVLAMNVMMAIISDPVVEAVGCEECPMHCKGKNANPTCDDGVCNCNV
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Disulfide Bond
31-47;34-52;38-54
PDB ID
1WM8
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
1 μM
Blocker
 [4]
 Target Info    KCa2 Inhibition rate
42 %
1 μM
Blocker
 [3]
 Target Info    Kv1.3 IC50
85.4 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1.2 IC50
530 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Shaker IC50
4.64 μM
 .
Blocker
 [4]
 Target Info    Kv1 IC50
5.48 μM
 .
Blocker
 [1], [2], [3]
References
Ref 1 Genomic organization of three neurotoxins active on small conductance Ca2+-activated potassium channels from the scorpion Buthus martensi Karsch. FEBS Lett. 1999 Jun 11;452(3):360-4. doi: 10.1016/s0014-5793(99)00651-1.
Ref 2 Molecular cloning and sequencing of two 'short chain' and two 'long chain' K(+) channel-blocking peptides from the Chinese scorpion Buthus martensii Karsch. FEBS Lett. 1999 Sep 3;457(3):509-14. doi: 10.1016/s0014-5793(99)01101-1.
Ref 3 Characterization of four toxins from Buthus martensi scorpion venom, which act on apamin-sensitive Ca2+-activated K+ channels. Eur J Biochem. 1997 Apr 15;245(2):457-64. doi: 10.1111/j.1432-1033.1997.00457.x.
Ref 4 Two dyad-free Shaker-type K? channel blockers from scorpion venom. Toxicon. 2012 Mar 1;59(3):402-7. doi: 10.1016/j.toxicon.2011.11.016. Epub 2012 Jan 4.
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