Peptide Information

General Information of This Peptide
Peptide ID
BTDP008523
Peptide Name
Potassium channel toxin alpha-KTx 9.1
Symonym
BmKK6; Neurotoxin BmP02
Species
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Uniprot Name
KAX91_MESMA
Alphafold ID
Q9NJP7
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1DU9
Sequence
MSRLFTLVLIVLAMNVMMAIISDPVVEAVGCEECPMHCKGKNAKPTCDDGVCNCNV
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Sequence Length
56
Mass (Da)
6015
Sequence Removed Signal Peptide
MSRLFTLVLIVLAMNVMMAIISDPVVEAVGCEECPMHCKGKNAKPTCDDGVCNCNV
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Disulfide Bond
31-47;34-52;38-54
PDB ID
1DU9
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus martensii
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.4 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    KCa2 Inhibition rate
12 %
1 μM
Blocker
 [2]
 Target Info    Kv7.1 Inhibition rate
23.3 %
10 μM
Blocker
 [2], [3], [4], [5]
 Target Info    Kv1.3 IC50
7 nM
 .
Blocker
 [2], [3], [4], [5]
 Target Info    Kv1 IC50
1.95 μM
 .
Blocker
 [2], [3], [4], [5]
 Target Info    Kv1.2 IC50
4.4 μM
 .
Blocker
 [2], [3], [4], [5]
 Target Info    Shaker IC50
20.44 μM
 .
Blocker
 [1]
References
Ref 1 Two dyad-free Shaker-type K? channel blockers from scorpion venom. Toxicon. 2012 Mar 1;59(3):402-7. doi: 10.1016/j.toxicon.2011.11.016. Epub 2012 Jan 4.
Ref 2 Characterization of four toxins from Buthus martensi scorpion venom, which act on apamin-sensitive Ca2+-activated K+ channels. Eur J Biochem. 1997 Apr 15;245(2):457-64. doi: 10.1111/j.1432-1033.1997.00457.x.
Ref 3 Molecular cloning and sequencing of two 'short chain' and two 'long chain' K(+) channel-blocking peptides from the Chinese scorpion Buthus martensii Karsch. FEBS Lett. 1999 Sep 3;457(3):509-14. doi: 10.1016/s0014-5793(99)01101-1.
Ref 4 Structural and functional diversity of acidic scorpion potassium channel toxins. PLoS One. 2012;7(4):e35154. doi: 10.1371/journal.pone.0035154. Epub 2012 Apr 12.
Ref 5 Solution structure of BmP02, a new potassium channel blocker from the venom of the Chinese scorpion Buthus martensi Karsch. Biochemistry. 2000 Nov 14;39(45):13669-75. doi: 10.1021/bi000860s.
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