Peptide Information

General Information of This Peptide
Peptide ID
BTDP008515
Peptide Name
Potassium channel toxin alpha-KTx 7.2
Symonym
Pandinotoxin-beta; Potassium channel-blocking toxin 3; Toxin PiTX-K-beta
Species
Pandinus imperator (Emperor scorpion)
Uniprot Name
KAX72_PANIM
Alphafold ID
P55928
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1C49
Sequence
TISCTNEKQCYPHCKKETGYPNAKCMNRKCKCFGR
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Sequence Length
35
Mass (Da)
4072
Sequence Removed Signal Peptide
TISCTNEKQCYPHCKKETGYPNAKCMNRKCKCFGR
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Disulfide Bond
4-25;10-30;14-32
PDB ID
1C49
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Scorpionidae
Genus: Pandinus
Species: Pandinus imperator
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Dissociation constant
0.795 nM
 .
Blocker
 [4]
 Target Info    Shaker Dissociation constant
140 nM
 .
Blocker
 [2]
 Target Info    Kv1 IC50
42 nM
 .
Blocker
 [2]
References
Ref 1 Three new toxins from the scorpion Pandinus imperator selectively block certain voltage-gated K+ channels. Mol Pharmacol. 1996 Nov;50(5):1167-77.
Ref 2 Two novel toxins from the venom of the scorpion Pandinus imperator show that the N-terminal amino acid sequence is important for their affinities towards Shaker B K+ channels. J Membr Biol. 1996 Jul;152(1):49-56. doi: 10.1007/s002329900084.
Ref 3 Structural and functional differences of two toxins from the scorpion Pandinus imperator. Proteins. 2000 Mar 1;38(4):441-9. doi: 10.1002/(sici)1097-0134(20000301)38:4<441::aid-prot9>3.0.co;2-l.
Ref 4 Effects of toxins Pi2 and Pi3 on human T lymphocyte Kv1.3 channels: the role of Glu7 and Lys24. J Membr Biol. 2001 Jan 1;179(1):13-25. doi: 10.1007/s002320010033.
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