Peptide Information

General Information of This Peptide
Peptide ID
BTDP008514
Peptide Name
Potassium channel toxin alpha-KTx 7.1
Symonym
Pandinotoxin-alpha; Potassium channel-blocking toxin 2; Toxin PiTX-K-alpha
Species
Pandinus imperator (Emperor scorpion)
Uniprot Name
KAX71_PANIM
Alphafold ID
P55927
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2PTA
Sequence
RGSVDYKDDDDKTISCTNPKQCYPHCKKETGYPNAKCMNRKCKCFGR
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Sequence Length
47
Mass (Da)
5434
Sequence Removed Signal Peptide
RGSVDYKDDDDKTISCTNPKQCYPHCKKETGYPNAKCMNRKCKCFGR
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Disulfide Bond
16-37;22-42;26-44
PDB ID
2PTA
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Scorpionidae
Genus: Pandinus
Species: Pandinus imperator
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Dissociation constant
0.044 nM
 .
Blocker
 [4]
 Target Info    Shaker Dissociation constant
8.2 nM
 .
Blocker
 [2]
 Target Info    Kv1.2 IC50
0.032 nM
 .
Blocker
 [2], [3]
 Target Info    Kv1 IC50
6 nM
 .
Blocker
 [2], [3]
References
Ref 1 Three new toxins from the scorpion Pandinus imperator selectively block certain voltage-gated K+ channels. Mol Pharmacol. 1996 Nov;50(5):1167-77.
Ref 2 Two novel toxins from the venom of the scorpion Pandinus imperator show that the N-terminal amino acid sequence is important for their affinities towards Shaker B K+ channels. J Membr Biol. 1996 Jul;152(1):49-56. doi: 10.1007/s002329900084.
Ref 3 Solution structure for Pandinus toxin K-alpha (PiTX-K alpha), a selective blocker of A-type potassium channels. Biochemistry. 1997 Mar 11;36(10):2763-71. doi: 10.1021/bi9628432.
Ref 4 Effects of toxins Pi2 and Pi3 on human T lymphocyte Kv1.3 channels: the role of Glu7 and Lys24. J Membr Biol. 2001 Jan 1;179(1):13-25. doi: 10.1007/s002320010033.
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