Peptide Information

General Information of This Peptide
Peptide ID
BTDP008475
Peptide Name
Potassium channel toxin alpha-KTx 2.1
Symonym
Noxiustoxin; Toxin II.11
Species
Centruroides noxius (Mexican scorpion)
Uniprot Name
KAX21_CENNO
Alphafold ID
P08815
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1SXM
Sequence
TIINVKCTSPKQCSKPCKELYGSSAGAKCMNGKCKCYNN
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Sequence Length
39
Mass (Da)
4202
Sequence Removed Signal Peptide
TIINVKCTSPKQCSKPCKELYGSSAGAKCMNGKCKCYNN
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Disulfide Bond
7-29;13-34;17-36
PDB ID
1SXM
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Centruroides
Species: Centruroides noxius
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa1.1 Dissociation constant
>25 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    KCa3.1 Dissociation constant
>25 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.3 Dissociation constant
>25 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.5 Dissociation constant
>25 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.1 Dissociation constant
>25 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.3 Dissociation constant
1 nM
 .
Blocker
 [3]
 Target Info    Kv1.3 Dissociation constant
1 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.2 Dissociation constant
2 nM
 .
Blocker
 [1], [2], [4]
 Target Info    Kv1.2 Dissociation constant
2 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    Kv1.3 Dissociation constant
6.8 nM
 .
Blocker
 [1], [2], [4]
 Target Info    Shaker Dissociation constant
160 nM
 .
Blocker
 [5- 16]
 Target Info    KCa1.1 Dissociation constant
450 nM
 .
Blocker
 [1- 16]
 Target Info    KCa3.1 Inhibition rate .
25 nM
Blocker
 [3]
 Target Info    Kv1.1 Inhibition rate .
25 nM
Blocker
 [3]
 Target Info    KCa1.1 Inhibition rate .
1 mM
Blocker
 [1], [2], [4]
 Target Info    Kir3.1/3.4 Inhibition rate .
1 μM
Blocker
 [1], [2], [4]
 Target Info    Kv1.5 Inhibition rate .
25 nM
Blocker
 [3]
 Target Info    Kir1.1 Inhibition rate .
2.5 μM
Blocker
 [17]
References
Ref 1 Charybdotoxin and noxiustoxin, two homologous peptide inhibitors of the K+ (Ca2+) channel. FEBS Lett. 1988 Jan 4;226(2):280-4. doi: 10.1016/0014-5793(88)81439-x.
Ref 2 Synthetic peptides corresponding to the sequence of noxiustoxin indicate that the active site of this K+ channel blocker is located on its amino-terminal portion. J Neural Transm. 1989;77(1):11-20. doi: 10.1007/BF01255815.
Ref 3 Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol. 1994 Jun;45(6):1227-34.
Ref 4 Determination of the three-dimensional solution structure of noxiustoxin: analysis of structural differences with related short-chain scorpion toxins. Biochemistry. 1995 Dec 26;34(51):16563-73. doi: 10.1021/bi00051a004.
Ref 5 Synthesis of Novel cis-2-Azetidinones from imines and aclychloride using triethylamine. Acta Chim Slov. 2023 Dec 4;70(4):628-633. doi: 10.17344/acsi.2023.8451.
Ref 6 Backward-Eulerian Footprint Modelling Based on the Adjoint Equation for Atmospheric and Urban-Terrain Dispersion. Boundary Layer Meteorol. 2023;188(1):159-183. doi: 10.1007/s10546-023-00807-z. Epub 2023 Apr 17.
Ref 7 Leaf spot on Alocasia macrorrhizos caused by Fusarium asiaticum in Sichuan, China. Plant Dis. 2022 Sep 11. doi: 10.1094/PDIS-04-22-0844-PDN. Online ahead of print.
Ref 8 Incidence and predictors of chronic kidney disease in type-II diabetes mellitus patients attending at the Amhara region referral hospitals, Ethiopia: A follow-up study. PLoS One. 2022 Jan 26;17(1):e0263138. doi: 10.1371/journal.pone.0263138. eCollection 2022.
Ref 9 A Method for More Accurate Determination of Resonance Frequency of the Cardiovascular System, and Evaluation of a Program to Perform It. Appl Psychophysiol Biofeedback. 2022 Mar;47(1):17-26. doi: 10.1007/s10484-021-09524-0. Epub 2021 Oct 16.
Ref 10 First Report of Fusarium wilt of Coleus forskohlii Caused by Fusarium oxysporum in China. Plant Dis. 2021 Jan 26. doi: 10.1094/PDIS-11-20-2489-PDN. Online ahead of print.
Ref 11 Shock waves from the inhomogeneous Boltzmann equation. Phys Rev E. 2019 Dec;100(6-1):062120. doi: 10.1103/PhysRevE.100.062120.
Ref 12 Classifying Changes to Preventive Interventions: Applying Adaptation Taxonomies. J Prim Prev. 2019 Feb;40(1):89-109. doi: 10.1007/s10935-018-00531-2.
Ref 13 Quantification of the passive and active biaxial mechanical behaviour and microstructural organization of rat thoracic ducts. J R Soc Interface. 2015 Jul 6;12(108):20150280. doi: 10.1098/rsif.2015.0280.
Ref 14 A model of mechanical interactions between heart and lungs. Philos Trans A Math Phys Eng Sci. 2009 Dec 13;367(1908):4741-57. doi: 10.1098/rsta.2009.0137.
Ref 15 Experimental test of nonlocal realistic theories without the rotational symmetry assumption. Phys Rev Lett. 2007 Nov 23;99(21):210406. doi: 10.1103/PhysRevLett.99.210406. Epub 2007 Nov 21.
Ref 16 Structures and phase transitions of the A7PSe6 (A = ag, Cu) argyrodite-type ionic conductors. III. alpha-Cu7PSe6. Acta Crystallogr B. 2000 Dec;56 (Pt 6):972-9. doi: 10.1107/s0108768100010260.
Ref 17 Purification, characterization, and synthesis of an inward-rectifier K+ channel inhibitor from scorpion venom. Biochemistry. 1997 Jun 10;36(23):6936-40. doi: 10.1021/bi9702849.
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