Peptide Information

General Information of This Peptide
Peptide ID
BTDP008467
Peptide Name
Potassium channel toxin alpha-KTx 15.3
Symonym
Toxin AmmTX3
Species
Androctonus mauritanicus mauritanicus (Scorpion)
Uniprot Name
KA153_ANDMA
Alphafold ID
P60208
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 6GGZ
Sequence
QIETNKKCQGGSCASVCRKVIGVAAGKCINGRCVCYP
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Sequence Length
37
Mass (Da)
3846
Sequence Removed Signal Peptide
QIETNKKCQGGSCASVCRKVIGVAAGKCINGRCVCYP
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Disulfide Bond
8-28;13-33;17-35
PDB ID
6GGZ
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Androctonus
Species: Androctonus mauritanicus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    A-type voltage-gated potassium channel Inhibition constant
131 nM
 . . [1- 5]
 Target Info    Kv4.2 Inhibition rate
40 %
500 nM
 . [1- 5]
 Target Info    Kv4.3 Inhibition rate
40 %
500 nM
 . [1- 5]
 Target Info    Kv4.3 Inhibition rate
80 - 90 %
500 nM
 . [1- 5]
 Target Info    Kv4.2 Inhibition rate
80-90 %
500 nM
 . [1- 5]
 Target Info    Kv11 IC50
7.9 μM
 .
Blocker
 [2]
References
Ref 1 Expanding the scorpion toxin alpha-KTX 15 family with AmmTX3 from Androctonus mauretanicus. Eur J Biochem. 2002 Dec;269(24):6037-41. doi: 10.1046/j.1432-1033.2002.03294.x.
Ref 2 A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K+ channels. Biochem Pharmacol. 2008 Sep 15;76(6):805-15. doi: 10.1016/j.bcp.2008.07.008. Epub 2008 Jul 18.
Ref 3 Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels. J Physiol. 2013 May 15;591(10):2419-27. doi: 10.1113/jphysiol.2012.248831. Epub 2013 Feb 25.
Ref 4 Kv4 channel blockade reduces motor and neuropsychiatric symptoms in rodent models of Parkinson's disease. Behav Pharmacol. 2015 Feb;26(1-2):91-100. doi: 10.1097/FBP.0000000000000107.
Ref 5 Synthesis by native chemical ligation and characterization of the scorpion toxin AmmTx3. Bioorg Med Chem. 2019 Jan 1;27(1):247-253. doi: 10.1016/j.bmc.2018.12.009. Epub 2018 Dec 6.
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