Peptide Information

General Information of This Peptide
Peptide ID
BTDP008450
Peptide Name
Potassium channel toxin alpha-KTx 1.3
Symonym
Iberiotoxin
Species
Hottentotta tamulus (Eastern Indian scorpion) (Mesobuthus tamulus)
Uniprot Name
KAX13_HOTTA
Alphafold ID
P24663
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P24663
Sequence
QFTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ
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Sequence Length
37
Mass (Da)
4254
Sequence Removed Signal Peptide
QFTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ
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Disulfide Bond
7-28;13-33;17-35
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Mesobuthus
Species: Mesobuthus tamulus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa1.1 Inhibition constant
0.25 nM
 .
Blocker
 [2]
 Target Info    KCa1.1 Inhibition constant
0.94 nM
 .
Blocker
 [3]
 Target Info    Kv1.3 Inhibition rate .
3 μM
Blocker
 [4]
 Target Info    Kir3.1/3.4 Inhibition rate .
1 μM
Blocker
 [2]
 Target Info    Kir1.1 Inhibition rate .
2.5 μM
Blocker
 [5]
 Target Info    KCa1.1 Effective concentration 50
5.81 nM
 .
Blocker
 [6]
References
Ref 1 Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J Biol Chem. 1990 Jul 5;265(19):11083-90.
Ref 2 Determination of the three-dimensional structure of iberiotoxin in solution by 1H nuclear magnetic resonance spectroscopy. Biochemistry. 1992 Sep 8;31(35):8151-9. doi: 10.1021/bi00150a006.
Ref 3 [125I]Iberiotoxin-D19Y/Y36F, the first selective, high specific activity radioligand for high-conductance calcium-activated potassium channels. Biochemistry. 1997 Feb 18;36(7):1943-52. doi: 10.1021/bi962074m.
Ref 4 Revealing the molecular determinants of neurotoxin specificity for calcium-activated versus voltage-dependent potassium channels. Biochemistry. 2007 May 8;46(18):5358-64. doi: 10.1021/bi700150t. Epub 2007 Apr 18.
Ref 5 Purification, characterization, and synthesis of an inward-rectifier K+ channel inhibitor from scorpion venom. Biochemistry. 1997 Jun 10;36(23):6936-40. doi: 10.1021/bi9702849.
Ref 6 Synthesis and biological evaluation of an iodinated iberiotoxin analogue, [mono-iodo-Tyr5, Phe36]-iberiotoxin. Int J Pept Protein Res. 1996 Aug;48(2):194-9. doi: 10.1111/j.1399-3011.1996.tb00831.x.
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