Peptide Information

General Information of This Peptide
Peptide ID
BTDP008449
Peptide Name
Potassium channel toxin alpha-KTx 1.2
Symonym
ChTX-Lq2; ChTx-d; Charybdotoxin-2; Lqh 18-2; Toxin 18-2
Species
Leiurus hebraeus (Deathstalker scorpion) (Leiurus quinquestriatus hebraeus)
Uniprot Name
KAX12_LEIHE
Alphafold ID
P45628
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 1LIR
Sequence
MKILSVLLLALIICSIIDWSEGQFTQESCTASNQCWSICKRLHNTNRGKCMNKKCRCYS
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Sequence Length
59
Mass (Da)
6772
Signal Sequence
MKILSVLLLALIICSIIDWSEG
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Sequence Removed Signal Peptide
QFTQESCTASNQCWSICKRLHNTNRGKCMNKKCRCYS
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Disulfide Bond
29-50;35-55;39-57
PDB ID
1LIR
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Scorpiones
Family: Buthidae
Genus: Leiurus
Species: Leiurus quinquestriatus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa1.1 Dissociation constant
43 nM
 .
Blocker
 [1], [2], [3], [4]
 Target Info    KCa1.1 Dissociation constant
43 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Kir1.1 Dissociation constant
410 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1 Inhibition constant
0.25 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Kir2.1 Inhibition rate .
3.5 μM
Blocker
 [5]
 Target Info    Kir3.1/3.4 Inhibition rate
5 %
1 μM
Blocker
 [6]
 Target Info    Kv1.1 IC50
1 nM
 .
Blocker
 [1], [2], [3]
 Target Info    Kv1.3 IC50
1 nM
 .
Blocker
 [1], [2], [3]
References
Ref 1 Dynamic diversification from a putative common ancestor of scorpion toxins affecting sodium, potassium, and chloride channels. J Mol Evol. 1999 Feb;48(2):187-96. doi: 10.1007/pl00006457.
Ref 2 Analysis of the blocking activity of charybdotoxin homologs and iodinated derivatives against Ca2+-activated K+ channels. J Membr Biol. 1989 Aug;109(3):269-81. doi: 10.1007/BF01870284.
Ref 3 Neuromuscular effects of some potassium channel blocking toxins from the venom of the scorpion Leiurus quinquestriatus hebreus. Toxicon. 1994 Nov;32(11):1433-43. doi: 10.1016/0041-0101(94)90415-4.
Ref 4 Solution structure of potassium channel-inhibiting scorpion toxin Lq2. Proteins. 1999 Mar 1;34(4):417-26. doi: 10.1002/(sici)1097-0134(19990301)34:4<417::aid-prot1>3.0.co;2-r.
Ref 5 Purification, characterization, and synthesis of an inward-rectifier K+ channel inhibitor from scorpion venom. Biochemistry. 1997 Jun 10;36(23):6936-40. doi: 10.1021/bi9702849.
Ref 6 A novel high-affinity inhibitor for inward-rectifier K+ channels. Biochemistry. 1998 Sep 22;37(38):13291-9. doi: 10.1021/bi981178p.
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