Peptide Information

General Information of This Peptide
Peptide ID
BTDP008423
Peptide Name
Lambda-theraphotoxin-Ec2b
Symonym
Kappa-theraphotoxin-Ec2b
Species
Eucratoscelus constrictus (African red-rump baboon spider)
Uniprot Name
TX2B_EUCCO
Alphafold ID
P0DQO6
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DQO6
Sequence
YCQKFLWTCDTERKCCEDMVCELWCKYKE
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Sequence Length
29
Mass (Da)
3685
Sequence Removed Signal Peptide
YCQKFLWTCDTERKCCEDMVCELWCKYKE
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Disulfide Bond
2-16;9-21;15-25
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Eucratoscelus
Species: Eucratoscelus constrictus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv Inhibition rate .
330 nM
Blocker
 [1]
 Target Info    Nav Inhibition rate .
330 nM
Blocker
 [1]
 Target Info    delayed-rectifier Kv Inhibition rate .
330 nM
Blocker
 [1]
 Target Info    HVA calcium channel Inhibition rate .
330 nM
Blocker
 [1]
 Target Info    M-LVA calcium channel Inhibition rate .
330 nM
Blocker
 [1]
 Target Info    transient 'A-type' Kv Inhibition rate .
330 nM
Blocker
 [1]
 Target Info    KCa1.1 IC50
25.3 nM
 .
Blocker
 [1]
 Target Info    KCa1.1 IC50
25.3 nM
 .
Blocker
 [1]
References
Ref 1 A novel family of insect-selective peptide neurotoxins targeting insect large-conductance calcium-activated K+ channels isolated from the venom of the theraphosid spider Eucratoscelus constrictus. Mol Pharmacol. 2011 Jul;80(1):1-13. doi: 10.1124/mol.110.070540. Epub 2011 Mar 29.
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