Target Information

General Information of This Target
Target ID
BTDT00164
Target Name
BK channel (pslo)
Target Bioclass
Transporter and channel
Uniprot ID
Q8I9V1
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Gene Name
pslo
Sequence
MSNCEEMTSVSPGEDDCLKVRKWWCFLLSSIFTFFAGLTIVLLWRAFAFLCCRKEPEFSP
NDPKQKEQKAARQGKQEFEGTFMTEAKDWAGELISGQTTTGRILVVLVFILSIASLIIYF
IDASSEEVERCQKWSNNITQQIDLAFNIFFMVYFFIRFIAASDKLWFMLEMYSFVDYFTI
PPSFVSIYLDRTWIGLRFLRALRLMTVPDILQYLNILKTSSSIRLAQLVSIFISVWLTAA
GIIHLLENSGDPLEFHNPQQLSYWTCVYFLIVTMSTVGYGDVYCQTVLGRTFLVFFLLVG
LAIFASSIPEIIELVGTRSKYGGEYKREHGKRHIVVCGHITYESVSHFLKDFLHEDREDV
DVEVVFLHRKPPDLELEGLFKRHFTTVEFFQGSIMNPIDLQRVKVHEADACLVLANKYCQ
DPDAEDAANIMRVISIKNYSDDIRVIIQLMQYHNKAYFLNIPSWDWKQGDDVICLAELKL
GFIAQSCLAPGFSTMMANLFAMRSFKTSPDIQSWQNDYLRGTGMEMYTETLSPTFIAMPF
AQATELCFTKLKLLLLAIEIKGEDGSDSKISINPRGAKIQANTQGFFIAQSAVEVKRAWF
YCKACHDDIKDETLIKKCKCKNYDHHPPPTFTPPELPKKVHVRGEAGREKEDSLMRNHRS
TPTAMVNSMSSSKQVNKVKPTVNRSTPDNMAVSPNQQPGGGGYNRPTSRGSGGNNMNNNG
GLQVGIADDQAKDFDFEKTEMKYDSTGMFHWGPAKSLEECILDRNQAAMTVLNGHVVVCL
FADPDSPLIGLRNLVMPLRASNFHYHELKHVVIVGSVDYIRREWKMLQNLPKISVLNGSP
LSRADLRAVNVNLCDMCVILSAKVPSNDDPTLADKEAILASLNIKAMTFDDTIGVLSQTA
AGEQDNLTPVGSPIVLQRRGSVYGANVPMITELVNDSNVQFLDQDDDDDPDTELYLTQPF
ACGTAFAVSVLDSLMSTTYFNQNALTLIRSLITGGATPELELILAEGAGLRGGYSTADSL
SNRDRCRVGQISLYDGPLAQFGEAGKYGDLFVAALKSYGMLCIGLYRFRDTSSSCDASSK
RYVITNPPDDFSLLPTDQVFVLMQFDPGLEYKPNRGTRGKDDNS

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Taxonomy ID
6978
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Insecta
Order: Blattodea
Family: Blattidae
Genus: Periplaneta
Species: Periplaneta americana
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Lambda-hexatoxin-Hv1c IC50
2.3 nM
 [1]
 Toxin Info    Lambda-theraphotoxin-Ec2a IC50
3.7 nM
 [2]
 Toxin Info    Lambda-theraphotoxin-Ec2a IC50
3.7 nM
 [2]
 Toxin Info    Lambda-theraphotoxin-Ec2c IC50
24.6 nM
 [2]
 Toxin Info    Lambda-theraphotoxin-Ec2c IC50
24.6 nM
 [2]
 Toxin Info    Lambda-theraphotoxin-Ec2b IC50
25.3 nM
 [2]
 Toxin Info    Lambda-theraphotoxin-Ec2b IC50
25.3 nM
 [2]
 Toxin Info    Lambda-hexatoxin-Hv1c IC50
240 nM
 [1]
References
Ref 1 The Janus-faced atracotoxins are specific blockers of invertebrate K(Ca) channels. FEBS J. 2008 Aug;275(16):4045-59. doi: 10.1111/j.1742-4658.2008.06545.x. Epub 2008 Jul 9.
Ref 2 A novel family of insect-selective peptide neurotoxins targeting insect large-conductance calcium-activated K+ channels isolated from the venom of the theraphosid spider Eucratoscelus constrictus. Mol Pharmacol. 2011 Jul;80(1):1-13. doi: 10.1124/mol.110.070540. Epub 2011 Mar 29.
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