Target Information

General Information of This Target
Target ID
BTDT00006
Target Name
Shab type I (Kv2)
Target Bioclass
Transporter and channel
Uniprot ID
B2Z8B1
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Gene Name
Kv2
Sequence
ISASPDKWKFFKGGLNIIDLFAILPYFVSLFLLETSKNATDQFQDVRRVVQVFRIMRILR
ILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKGEPQTKFISIPE
TFWWAGITMTTVGYGDICPTTPLGKVIGTVCCICGVLVAALPIPIIVNNFAEFYKNQM

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Taxonomy ID
6976
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Insecta
Order: Blattodea
Family: Blattidae
Genus: Blatta
Species: Blatta orientalis
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Lambda-theraphotoxin-Ec2b Inhibition rate . [1]
 Toxin Info    Lambda-theraphotoxin-Ec2c Inhibition rate . [1]
 Toxin Info    Lambda-theraphotoxin-Ec2a Inhibition rate
10 %
 [1]
 Toxin Info    Insect toxin mu-NPTX-Nc1a Inhibition rate
25 %
 [2]
References
Ref 1 A novel family of insect-selective peptide neurotoxins targeting insect large-conductance calcium-activated K+ channels isolated from the venom of the theraphosid spider Eucratoscelus constrictus. Mol Pharmacol. 2011 Jul;80(1):1-13. doi: 10.1124/mol.110.070540. Epub 2011 Mar 29.
Ref 2 An insecticidal toxin from Nephila clavata spider venom. Amino Acids. 2017 Jul;49(7):1237-1245. doi: 10.1007/s00726-017-2425-2. Epub 2017 May 11.
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