Peptide Information

General Information of This Peptide
Peptide ID
BTDP008411
Peptide Name
Kunitz-type serine protease inhibitor homolog delta-dendrotoxin
Symonym
Dendrotoxin delta-DaTX; Protease inhibitor K; Toxin C13S1C3; Venom basic protease inhibitor K
Species
Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Uniprot Name
VKTHD_DENAN
Alphafold ID
P00982
3D Structure
Download
2D Sequence
3D Structure
Source
Alphafold db: P00982
Sequence
AAKYCKLPVRYGPCKKKIPSFYYKWKAKQCLPFDYSGCGGNANRFKTIEECRRTCVG
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Sequence Length
57
Mass (Da)
6574
Sequence Removed Signal Peptide
AAKYCKLPVRYGPCKKKIPSFYYKWKAKQCLPFDYSGCGGNANRFKTIEECRRTCVG
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Disulfide Bond
5-55;14-38;30-51
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Dendroaspis
Species: Dendroaspis angusticeps
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1 Dissociation constant
0.1 nM
 .
Blocker
 [1], [3]
 Target Info    ShaKv1.1 Dissociation constant
2 nM
 .
Blocker
 [3]
 Target Info    Kv1.6 Dissociation constant
23 nM
 .
Blocker
 [1], [3]
 Target Info    Kir1.1 Dissociation constant
152 nM
 .
Blocker
 [1], [3]
 Target Info    KCa1.1 Dissociation constant
390 nM
 .
Blocker
 [1], [3]
 Target Info    Shaker Inhibition rate .
100 nM
Blocker
 [4]
 Target Info    Kir3.1/3.4 Inhibition rate .
1 μM
Blocker
 [1], [3]
 Target Info    Kir2.1 Inhibition rate .
100 nM
Blocker
 [4]
 Target Info    Kv1.1 Effective concentration 50
1.8 nM
 .
Blocker
 [5]
References
Ref 1 Snake venoms. The amino acid sequences of two proteinase inhibitor homologues from Dendroaspis angusticeps venom. Hoppe Seylers Z Physiol Chem. 1980 May;361(5):661-74. doi: 10.1515/bchm2.1980.361.1.661.
Ref 2 Four polypeptide components of green mamba venom selectively block certain potassium channels in rat brain synaptosomes. Mol Pharmacol. 1988 Aug;34(2):152-9.
Ref 3 Energetic and structural interactions between delta-dendrotoxin and a voltage-gated potassium channel. J Mol Biol. 2000 Mar 10;296(5):1283-94. doi: 10.1006/jmbi.2000.3522.
Ref 4 A snake toxin inhibitor of inward rectifier potassium channel ROMK1. Biochemistry. 1998 Oct 20;37(42):14867-74. doi: 10.1021/bi980929k.
Ref 5 The relative potencies of dendrotoxins as blockers of the cloned voltage-gated K+ channel, mKv1.1 (MK-1), when stably expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Mar;120(6):1029-34. doi: 10.1038/sj.bjp.0701004.
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