Peptide Information

General Information of This Peptide
Peptide ID
BTDP008383
Peptide Name
Kappa-conotoxin ViTx
Symonym
I2-superfamily conotoxin ViTx
Species
Conus virgo (Virgin cone)
Uniprot Name
CI2_CONVR
Alphafold ID
Q7YZS9
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: Q7YZS9
Sequence
MMFRLTSVSCFLLVIACLNLFQVVLTSRCFPPGIYCTPYLPCCWGICCGTCRNVCHLRIG
KRATFQE
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Sequence Length
67
Mass (Da)
7599
Signal Sequence
MMFRLTSVSCFLLVIACLNLFQVVLT
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Sequence Removed Signal Peptide
SRCFPPGIYCTPYLPCCWGICCGTCRNVCHLRIGKRATFQE
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Disulfide Bond
29-48;36-51;42-43;47-55
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus virgo
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.2 Inhibition rate .
2 μM
 . [1], [2]
 Target Info    Kir2.1 Inhibition rate .
2 μM
 . [1], [2]
 Target Info    Kv11 Inhibition rate .
2 μM
 . [1], [2]
 Target Info    Kv1 IC50
1.59 μM
 . . [1], [2]
 Target Info    Kv1.3 IC50
2.09 μM
 . . [1], [2]
References
Ref 1 A novel conotoxin inhibiting vertebrate voltage-sensitive potassium channels. Toxicon. 2003 Jul;42(1):43-52. doi: 10.1016/s0041-0101(03)00099-0.
Ref 2 Novel conopeptides of the I-superfamily occur in several clades of cone snails. Toxicon. 2004 Oct;44(5):539-48. doi: 10.1016/j.toxicon.2004.07.006.
Ref 3 I-superfamily conotoxins: sequence and structure analysis. In Silico Biol. 2005;5(5-6):557-71.
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