Peptide Information

General Information of This Peptide
Peptide ID
BTDP008382
Peptide Name
Kappa-conotoxin SrXIA
Symonym
I2-superfamily conotoxin sr11a
Species
Conus spurius (Alphabet cone)
Uniprot Name
I2BA_CONSP
Alphafold ID
P0C615
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0C615
Sequence
CRTEGMSC[Gla][Gla]NQQCCWRSCCRGECEAPCRFGP
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Sequence Length
32
Mass (Da)
3739
Sequence Removed Signal Peptide
CRTEGMSC[Gla][Gla]NQQCCWRSCCRGECEAPCRFGP
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Disulfide Bond
1-15;8-20;14-24;19-28
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus spurius
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Kv1.3 Inhibition rate .
640 nM
 . [1], [2]
 Target Info    Kv1.6 Inhibition rate
58 %
640 nM
 . [1], [2]
 Target Info    Kv1.2 Inhibition rate
66 %
640 nM
 . [1], [2]
References
Ref 1 I-conotoxins in vermivorous species of the West Atlantic: peptide sr11a from Conus spurius. Peptides. 2007 Jan;28(1):18-23. doi: 10.1016/j.peptides.2006.08.024. Epub 2006 Dec 12.
Ref 2 Peptide sr11a from Conus spurius is a novel peptide blocker for Kv1 potassium channels. Peptides. 2010 Jul;31(7):1287-91. doi: 10.1016/j.peptides.2010.04.007. Epub 2010 Apr 18.
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