Peptide Information

General Information of This Peptide
Peptide ID
BTDP008356
Peptide Name
Conorfamide-Sr3
Symonym
Cono-RFamide-Sr3
Species
Conus spurius (Alphabet cone)
Uniprot Name
CRFA3_CONSP
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
ATSGPMGWLPVFYRF
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Sequence Length
15
Mass (Da)
1729
Sequence Removed Signal Peptide
ATSGPMGWLPVFYRF
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        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus spurius
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Shaker Dissociation constant
2.7 μM
 .
Blocker
 [1], [2]
 Target Info    Shaker Dissociation constant
2.7 μM
 .
Blocker
 [1]
 Target Info    Shab Inhibition rate .
5 μM
Blocker
 [1]
 Target Info    Shal Inhibition rate .
5 μM
Blocker
 [1]
 Target Info    Shaw Inhibition rate .
5 μM
Blocker
 [1]
 Target Info    Kv1.4 Inhibition rate .
100 μM
Blocker
 [2]
 Target Info    Kv10 Inhibition rate .
100 μM
Blocker
 [1]
 Target Info    Kv1.5 Inhibition rate
5 %
100 μM
Blocker
 [2]
 Target Info    Kv1.6 IC50
2.7 μM
 .
Blocker
 [2]
 Target Info    Kv1.6 IC50
2.7 μM
 .
Blocker
 [1], [2]
 Target Info    Kv1.3 IC50
24 μM
 .
Blocker
 [2]
 Target Info    Kv1.3 IC50
24 μM
 .
Blocker
 [1], [2]
References
Ref 1 Conorfamide-Sr3, a structurally novel specific inhibitor of the Shaker K(+) channel. Toxicon. 2017 Nov;138:53-58. doi: 10.1016/j.toxicon.2017.07.024. Epub 2017 Jul 31.
Ref 2 Studies of Conorfamide-Sr3 on Human Voltage-Gated Kv1 Potassium Channel Subtypes. Mar Drugs. 2020 Aug 13;18(8):425. doi: 10.3390/md18080425.
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