Target Information

General Information of This Target
Target ID
BTDT00065
Target Name
Neuronal acetylcholine receptor subunit alpha-3 (chrna3)
Target Bioclass
Receptor
Uniprot ID
P18845
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Gene Name
chrna3
Synonym
GF-alpha-3
Sequence
MNSASRITLFFLLTVLITQECLSSKGEDRLFRRLFRRYNQFIRPVENVSDPVTVEFEVSI
SQLVKVDEVNQIMETNLWLRHIWNDYKLKWLPAEFDGIEFIRVPSNKIWRPDIVLYNNAV
GDFLVEDKTKALLKYDGTITWVPPAIFKSSCPMDITYFPFDYQNCSMKFGSWTYDKAKID
LVLIGSKVNLKDFWESGEWEIIDAPGYKHDIKYNCCEEIYPDITYSFYIRRLPLFYTINL
IIPCLLISFLTILVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYL
LFTMIFVTLSIVITVFVLNVHYRTPMTHTMPSWVRTVFLRALPRVMLMRRPIDLSESSGK
GGGEIAGSSGTGGGRGAEGKKMKSSASQQGAMNSLEFGEGKAALEGKKGGCPCHPIKEAI
EGDCGKVSRQLTPQAINTVVTFSVVSPEIKQAIESVKYIAENMRSRNKAKEVEDDWKYVA
MVIDRIFLWVFVLVCVLGTLGLFLQPLIGFFS

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Family
the ligand-gated ion channel (TC 1.A.9) family
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

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Taxonomy ID
7957
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Kingdom: Metazoa
Phylum: Chordata
Class: Actinopteri
Order: Cypriniformes
Family: Cyprinidae
Genus: Carassius
Species: Carassius auratus
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Conotoxin MIIIJ IC50
0.1 μM
 [1]
References
Ref 1 M-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish. Toxins (Basel). 2020 Mar 21;12(3):197. doi: 10.3390/toxins12030197.
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