Peptide Information

General Information of This Peptide
Peptide ID
BTDP004935
Peptide Name
Mu-theraphotoxin-Tp1a
Symonym
Protoxin III
Species
Thrixopelma pruriens (Peruvian green velvet tarantula)
Uniprot Name
HPR3_THRPR
Alphafold ID
P0DL64
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2MXM
Sequence
DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI
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Sequence Length
33
Mass (Da)
3809
Sequence Removed Signal Peptide
DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI
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Disulfide Bond
2-17;9-22;16-29
PDB ID
2MXM
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Thrixopelma
Species: Thrixopelma pruriens
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR Inhibition rate .
5 μM
 . [1]
 Target Info    Cav Inhibition rate .
5 μM
 . [1]
 Target Info    Nav1.7 IC50
2.1 nM
 . . [1]
References
Ref 1 Identification and Characterization of ProTx-III [-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens. Mol Pharmacol. 2015 Aug;88(2):291-303. doi: 10.1124/mol.115.098178. Epub 2015 May 15.
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