Peptide Information

General Information of This Peptide
Peptide ID
BTDP004930
Peptide Name
Mu-theraphotoxin-Phlo1a
Symonym
Mu-TRTX-Phlo1a
Species
Phlogius sp. (Tarantula spider)
Uniprot Name
HM1A_PHLSP
Alphafold ID
P0DL57
3D Structure
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2D Sequence
3D Structure
Source
Alphafold db: P0DL57
Sequence
MKVSVLITLAVLGVMFVWTSAAEQEDHGSDRRDSPALLKNLLGEEVFQSEERACRELLGG
CSKDSDCCAHLECRKKWPYHCVWDWTIGK
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Sequence Length
89
Mass (Da)
10085
Signal Sequence
MKVSVLITLAVLGVMFVWTSA
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Sequence Removed Signal Peptide
AEQEDHGSDRRDSPALLKNLLGEEVFQSEERACRELLGGCSKDSDCCAHLECRKKWPYHC
VWDWTIGK
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Disulfide Bond
54-68;61-73;67-81
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Phlogius
Species: Phlogius sp. CYC-2015
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.5 Inhibition rate
<20 %
1 μM
 . [1]
 Target Info    Nav1.2 Inhibition rate
<20 %
1 μM
 . [1]
 Target Info    Nav1.7 IC50
459 nM
 . . [1]
References
Ref 1 Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula. Toxins (Basel). 2015 Jun 30;7(7):2494-513. doi: 10.3390/toxins7072494.
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