Peptide Information

General Information of This Peptide
Peptide ID
BTDP004853
Peptide Name
Mambalgin-1
Symonym
Pi-Dp1
Species
Dendroaspis polylepis polylepis (Black mamba)
Uniprot Name
3SX1_DENPO
Alphafold ID
P0DKR6
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 2MJY
Sequence
MKTLLLTLLVVTIVCLDLGYSLKCYQHGKVVTCHRDMKFCYHNTGMPFRNLKLILQGCSS
SCSETENNKCCSTDRCNK
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Sequence Length
78
Mass (Da)
8853
Signal Sequence
MKTLLLTLLVVTIVCLDLGYS
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Sequence Removed Signal Peptide
LKCYQHGKVVTCHRDMKFCYHNTGMPFRNLKLILQGCSSSCSETENNKCCSTDRCNK
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Disulfide Bond
24-40;33-58;62-70;71-76
PDB ID
2MJY , 5DO6 , 5DU1 , 5DZ5 , 7CFT
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Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Dendroaspis
Species: Dendroaspis polylepis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    acid-sensing ion channel (ASIC) IC50
3.4 - 55 nM
 . . [1- 7]
 Target Info    acid-sensing ion channel (ASIC) IC50
22.2 - 203 nM
 . . [1- 7]
 Target Info    ASIC1a-ASIC2b IC50
61 nM
 . . [1- 7]
 Target Info    acid-sensing ion channel (ASIC) IC50
72 nM
 . . [1- 7]
 Target Info    ASIC1a IC50
123.6 nM
 . . [1- 7]
 Target Info    ASIC1b IC50
127 - 580 nM
 . . [1- 7]
 Target Info    ASIC1a-ASIC2b IC50
152 - 252 nM
 . . [1- 7]
References
Ref 1 Black mamba venom peptides target acid-sensing ion channels to abolish pain. Nature. 2012 Oct 25;490(7421):552-5. doi: 10.1038/nature11494. Epub 2012 Oct 3.
Ref 2 Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels. Toxicon. 2013 Dec 1;75:187-204. doi: 10.1016/j.toxicon.2013.04.008. Epub 2013 Apr 26.
Ref 3 Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells. Chem Commun (Camb). 2015 May 11;51(38):8153-6. doi: 10.1039/c5cc01418b. Epub 2015 Apr 15.
Ref 4 Analgesic effects of mambalgin peptide inhibitors of acid-sensing ion channels in inflammatory and neuropathic pain. Pain. 2016 Mar;157(3):552-559. doi: 10.1097/j.pain.0000000000000397.
Ref 5 One-pot hydrazide-based native chemical ligation for efficient chemical synthesis and structure determination of toxin Mambalgin-1. Chem Commun (Camb). 2014 Jun 4;50(44):5837-9. doi: 10.1039/c4cc00779d.
Ref 6 Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition. J Biol Chem. 2016 Feb 5;291(6):2616-29. doi: 10.1074/jbc.M115.702373. Epub 2015 Dec 17.
Ref 7 Cryo-EM structure of the ASIC1a-mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect. Cell Discov. 2018 Jun 5;4:27. doi: 10.1038/s41421-018-0026-1. eCollection 2018.
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