Peptide Information

General Information of This Peptide
Peptide ID
BTDP003859
Peptide Name
Alpha-elapitoxin-Ls2a
Symonym
Long neurotoxin Ls3; LsIII; Neurotoxin 1; Neurotoxin alpha
Species
Laticauda semifasciata (Black-banded sea krait) (Pseudolaticauda semifasciata)
Uniprot Name
3L21_LATSE
Alphafold ID
P01379
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 1LSI
Sequence
MKTLLLTLVVVTIVCLDLGYTRECYLNPHDTQTCPSGQEICYVKSWCNAWCSSRGKVLEF
GCAATCPSVNTGTEIKCCSADKCNTYP
   Click to Show/Hide
Sequence Length
87
Mass (Da)
9551
Signal Sequence
MKTLLLTLVVVTIVCLDLGYT
   Click to Show/Hide
Sequence Removed Signal Peptide
RECYLNPHDTQTCPSGQEICYVKSWCNAWCSSRGKVLEFGCAATCPSVNTGTEIKCCSAD
KCNTYP
   Click to Show/Hide
Disulfide Bond
24-41;34-62;47-51;66-77;78-83
PDB ID
1LSI
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Laticauda
Species: Laticauda semifasciata
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-7 Dissociation constant
3 nM
 . . [1- 6]
 Target Info    nAChR alpha-5-beta-2-gamma-2 Inhibition rate
33 %
10 μM
 . [1- 6]
 Target Info    nAChR alpha-2-beta-2-gamma-2 Inhibition rate
39 %
10 μM
 . [1- 6]
 Target Info    nAChR alpha-1-beta-3-gamma-2 Inhibition rate
83 %
10 μM
 . [1- 6]
References
Ref 1 Complete nucleotide sequences of cDNAs encoding long chain alpha-neurotoxins from sea krait, Laticauda semifasciata. Toxicon. 1999 Jan;37(1):181-5. doi: 10.1016/s0041-0101(98)00181-0.
Ref 2 Molecular evolution and diversification of snake toxin genes, revealed by analysis of intron sequences. Gene. 2003 Aug 14;313:111-8. doi: 10.1016/s0378-1119(03)00637-1.
Ref 3 The primary structure of the toxin Laticauda semifasciata III, a weak and reversibly acting neurotoxin from the venom of a sea snake, Laticauda semifasciata. Biochem J. 1974 Aug;141(2):389-400. doi: 10.1042/bj1410389.
Ref 4 Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor. J Biol Chem. 1997 Sep 26;272(39):24279-86. doi: 10.1074/jbc.272.39.24279.
Ref 5 Neurotoxins from snake venoms and -conotoxin ImI inhibit functionally active ionotropic -aminobutyric acid (GABA) receptors. J Biol Chem. 2015 Sep 11;290(37):22747-58. doi: 10.1074/jbc.M115.648824. Epub 2015 Jul 28.
Ref 6 Solution structure of LSIII, a long neurotoxin from the venom of Laticauda semifasciata. Biochemistry. 1996 Jan 16;35(2):418-26. doi: 10.1021/bi9520287.
Data Quality & Feedback

Help us maintain data quality by reporting any errors or inaccuracies you may find.

samedaypayday.com visits since 2024

If you find any error in data or bug in web service, please kindly report it to biodb_contact@163.com et al.