Target Information

General Information of This Target
Target ID
BTDT10138
Target Name
Nicotinic acetylcholine receptor (nAChR) alpha-5-beta-2-gamma-2
Target Bioclass
Receptor
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N.A.
Toxin Information Related to This Target
                           Toxin Name Activity Data Type Activity Data Reference
 Toxin Info    Alpha-elapitoxin-Ls2a Inhibition rate
33 %
 [1- 6]
References
Ref 1 Complete nucleotide sequences of cDNAs encoding long chain alpha-neurotoxins from sea krait, Laticauda semifasciata. Toxicon. 1999 Jan;37(1):181-5. doi: 10.1016/s0041-0101(98)00181-0.
Ref 2 Molecular evolution and diversification of snake toxin genes, revealed by analysis of intron sequences. Gene. 2003 Aug 14;313:111-8. doi: 10.1016/s0378-1119(03)00637-1.
Ref 3 The primary structure of the toxin Laticauda semifasciata III, a weak and reversibly acting neurotoxin from the venom of a sea snake, Laticauda semifasciata. Biochem J. 1974 Aug;141(2):389-400. doi: 10.1042/bj1410389.
Ref 4 Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor. J Biol Chem. 1997 Sep 26;272(39):24279-86. doi: 10.1074/jbc.272.39.24279.
Ref 5 Neurotoxins from snake venoms and -conotoxin ImI inhibit functionally active ionotropic -aminobutyric acid (GABA) receptors. J Biol Chem. 2015 Sep 11;290(37):22747-58. doi: 10.1074/jbc.M115.648824. Epub 2015 Jul 28.
Ref 6 Solution structure of LSIII, a long neurotoxin from the venom of Laticauda semifasciata. Biochemistry. 1996 Jan 16;35(2):418-26. doi: 10.1021/bi9520287.
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