Peptide Information

General Information of This Peptide
Peptide ID
BTDP002566
Peptide Name
Alpha-elapitoxin-Dpp2d
Symonym
Alpha-EPTX-Dpp2d
Species
Dendroaspis polylepis polylepis (Black mamba)
Uniprot Name
3L24_DENPO
Alphafold ID
C0HJD7
3D Structure
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2D Sequence
3D Structure
Source
RSCB PDB: 4LFT
Sequence
RTCNKTFSDQSKICPPGENICYTKTWCDAFCSQRGKRVELGCAATCPKVKAGVEIKCCST
DNCNKFQFGKPR
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Sequence Length
72
Mass (Da)
8002
Sequence Removed Signal Peptide
RTCNKTFSDQSKICPPGENICYTKTWCDAFCSQRGKRVELGCAATCPKVKAGVEIKCCST
DNCNKFQFGKPR
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Disulfide Bond
3-21;14-42;27-31;46-57;58-63
PDB ID
4LFT , 8DA0
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Lepidosauria
Order: Squamata
Family: Elapidae
Genus: Dendroaspis
Species: Dendroaspis polylepis
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    nAChR alpha-3/beta-2 Inhibition rate .
1 μM
 . [1]
 Target Info    nAChR alpha-3/beta-4 Inhibition rate .
1 μM
 . [1]
 Target Info    lymnaea stagnalis acetylcholine-binding protein (Ls-AChBP) IC50
4.9 nM
 . . [1]
 Target Info    nAChR alpha-7 IC50
58 nM
 . . [1]
 Target Info    nAChR muscular IC50
114 nM
 . . [1]
References
Ref 1 Isolation and structural and pharmacological characterization of -elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom. Biochemistry. 2014 Jun 17;53(23):3758-66. doi: 10.1021/bi5004475. Epub 2014 Jun 5.
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