Peptide Information

General Information of This Peptide
Peptide ID
BTDP001739
Peptide Name
Mu-theraphotoxin-Os1a
Symonym
Cyriotoxin-1a; Mu-theraphotoxin-Cs1a
Species
Omothymus schioedtei (Malaysian earth tiger tarantula) (Cyriopagopus schioedtei)
Uniprot Name
TXNA1_OMOSC
Alphafold ID
A0A4V8GZX0
3D Structure
Download
2D Sequence
3D Structure
Source
RSCB PDB: 6GFT
Sequence
ECKGFGKSCVPGKNECCSGLTCSNKHKWCKVLL
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Sequence Length
33
Mass (Da)
3588
Sequence Removed Signal Peptide
ECKGFGKSCVPGKNECCSGLTCSNKHKWCKVLL
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Disulfide Bond
2-17;9-22;16-29
PDB ID
6GFT
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Kingdom: Metazoa
Phylum: Arthropoda
Class: Arachnida
Order: Araneae
Family: Theraphosidae
Genus: Cyriopagopus
Species: Cyriopagopus schioedtei
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.7 IC50
52.7 - 129.5 nM
 . . [1]
 Target Info    Nav1.1 IC50
72 nM
 . . [1]
 Target Info    Nav1.2 IC50
75.5 nM
 . . [1]
 Target Info    Nav1.6 IC50
115 nM
 . . [1]
 Target Info    Nav1.3 IC50
306.6 nM
 . . [1]
 Target Info    Nav1.5 IC50
>10 μM
 . . [1]
 Target Info    Nav1.8 IC50
>10 μM
 . . [1]
 Target Info    Nav1.4 IC50
7.7 μM
 . . [1]
References
Ref 1 From identification to functional characterization of cyriotoxin-1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei. Br J Pharmacol. 2019 May;176(9):1298-1314. doi: 10.1111/bph.14628. Epub 2019 Apr 9.
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