Peptide Information

General Information of This Peptide
Peptide ID
BTDP001508
Peptide Name
O-MrVIB
Species
Conus marmoreus (Marble cone)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
CSKKWEYCIVPILGFVYCCPGLICGPFVCV
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Sequence Length
30
Mass (Da)
3341
Sequence Removed Signal Peptide
CSKKWEYCIVPILGFVYCCPGLICGPFVCV
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Disulfide Bond
1-19;8-24;18-29
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus marmoreus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.8 IC50
102 nM
 . . [1]
 Target Info    Nav1.2 IC50
1 μM
 . . [1]
 Target Info    Nav1.3 IC50
1 μM
 . . [1]
 Target Info    Nav1.5 IC50
1 μM
 . . [1]
 Target Info    Nav1.7 IC50
1 μM
 . . [1]
References
Ref 1 muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):17030-5. doi: 10.1073/pnas.0601819103. Epub 2006 Oct 31.
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