Peptide Information

General Information of This Peptide
Peptide ID
BTDP001507
Peptide Name
O- MrVIA
Species
Conus magnificus (Magnificent cone) (Darioconus magnificus)
3D Structure
Download
2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Sequence
CRKKWEYCIVPILGFIYCCPGLICGPFVCV
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Sequence Length
30
Mass (Da)
3424
Sequence Removed Signal Peptide
CRKKWEYCIVPILGFIYCCPGLICGPFVCV
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Disulfide Bond
1-19;8-24;18-29
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Kingdom: Metazoa
Phylum: Mollusca
Class: Gastropoda
Order: Neogastropoda
Family: Conidae
Genus: Conus
Species: Conus magnificus
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    Nav1.3 IC50
2.2 ± 0.3 mM
 . . [1]
 Target Info    Nav1.1 IC50
3.3 ± 0.1 mM
 . . [1]
 Target Info    Nav1.5 IC50
3.9 ± 0.9 mM
 . . [1]
 Target Info    Nav1.6 IC50
4.67 ± 0.5 mM
 . . [1]
 Target Info    Nav1.7 IC50
5.5 ± 0.9 mM
 . . [1]
 Target Info    Nav1.2 IC50
6.3 ± 0.7 mM
 . . [1]
 Target Info    Nav1.4 IC50
81 ± 16 nM
 . . [1]
 Target Info    Nav1.8 IC50
529 ± 50 nM
 . . [1]
References
Ref 1 Isolation, characterization and total regioselective synthesis of the novel O-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels. Biochem Pharmacol. 2012 Aug 15;84(4):540-8. doi: 10.1016/j.bcp.2012.05.008. Epub 2012 May 16.
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