Peptide Information

General Information of This Peptide
Peptide ID
BTDP001074
Peptide Name
MTX (K23A)
Symonym
MTX (K23A)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
VSCTGSKDCYAPCRKQTGCPNAKCINKSCKCYGC
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Mutant Sequence
VSCTGSKDCYAPCRKQTGCPNAACINKSCKCYGC
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Sequence Length
34
Mass(Da)
3555
Sequence Removed Signal Peptide
VSCTGSKDCYAPCRKQTGCPNAACINKSCKCYGC
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa3.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate .
100 nM
Blocker
 [1]
 Target Info    KCa2.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    KCa2.2 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    KCa2.3 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.2 IC50
170 nM
 .
Blocker
 [2]
References
Ref 1 Maurotoxin: a potent inhibitor of intermediate conductance Ca2+-activated potassium channels. Mol Pharmacol. 2003 Feb;63(2):409-18. doi: 10.1124/mol.63.2.409.
Ref 2 The 'functional' dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels. Biochem J. 2004 Jan 1;377(Pt 1):25-36. doi: 10.1042/BJ20030115.
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