Peptide Information

General Information of This Peptide
Peptide ID
BTDP000914
Peptide Name
Toxin MeKTx13-3 (D19K)
Symonym
Toxin MeKTx13-3 (D19K)
3D Structure
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2D Sequence
3D Structure
Source
Predict by Alphafold2
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Alphafold Parameters: msa_mode: mmseqs2_uniref_env model_type: auto num_recycles: auto
Original Sequence
VGINVKCKHSGQCLKPCKDAGMRFGKCINGKCDCTPK
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Mutant Sequence
VGINVKCKHSGQCLKPCKKAGMRFGKCINGKCDCTPK
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Sequence Length
37
Mass(Da)
3976
Sequence Removed Signal Peptide
VGINVKCKHSGQCLKPCKKAGMRFGKCINGKCDCTPK
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N.A.
Full List of Activity Data of This Peptide Toxin
                        Target Name Activity Data Type Activity Data Concentration Note Reference
 Target Info    KCa3.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    KCa2.2 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    KCa2.3 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.2 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv7.1 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv11 Inhibition rate .
1 μM
Blocker
 [1]
 Target Info    Kv1.3 IC50
0.375 nM
 .
Blocker
 [1]
References
Ref 1 Toxin acidic residue evolutionary function-guided design of de novo peptide drugs for the immunotherapeutic target, the Kv1.3 channel. Sci Rep. 2015 May 8;5:9881. doi: 10.1038/srep09881.
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